Few legitimate studies have been done on ASMR, and even fewer have discussed the link between it and frisson specifically. At this time[when?], much of the data on ASMR comes from primarily anecdotal sources.[citation needed] Although ASMR and frisson are "interrelated in that they appear to arise through similar physiological mechanisms", individuals who have experienced both describe them as qualitatively different, with different kinds of triggers.[58] A 2018 fMRI study showed that the major brain regions already known to be activated in frisson are also activated in ASMR,[29] and suggests that "the similar pattern of activation of both ASMR and frisson could explain their subjective similarities, such as their short duration and tingling sensation".

He posted earlier this year on the ASMR subreddit, calling for volunteers, and completed the study in May. First, he looked at how ASMR videos affected "normal people"—18 Dartmouth undergrads. "In the second study we selected only people we knew could reliably experience and report ASMR," he says. "For this we used 10 subjects, most of whom were people from the subreddit who could commute to Hanover, New Hampshire. In this second study we asked the participants to bring in videos that they knew would trigger their ASMR. They then watched the videos in an MRI, while indicating periods of ASMR with a button press."

It’s not really a physical feeling if that makes sense, but there is a powerful reaction to the sounds nonetheless, to the point where I’m instinctively arching my neck, and a feeling does wash over you that is truly unique, almost addictive. What I don’t fully understand is why my mind chose just now to react when I haven’t had anything close to an ASMR experience before. I’d say that I’ve just found the right trigger, but I’m even reacting to videos that did nothing for me in the past. Like something clicked in my head recently.
ASMR is usually precipitated by stimuli referred to as 'triggers'.[11] ASMR triggers, which are most commonly auditory and visual, may be encountered through the interpersonal interactions of daily life. Additionally, ASMR is often triggered by exposure to specific audio and video. Such media may be specially made with the specific purpose of triggering ASMR or originally created for other purposes and later discovered to be effective as a trigger of the experience.[4]