In the first peer-reviewed article on ASMR, published in Perspectives in Biology in summer 2013, Nitin Ahuja, who was at the time of publication a medical resident at the University of Virginia, invited conjecture on whether the receipt of simulated medical attention might have some tangible therapeutic value for the recipient, comparing the purported positive outcome of clinical role play ASMR videos with the themes of the novel Love in the Ruins by author and physician Walker Percy, published in 1971.
In 2012, Steven Novella, a neurologist at the Yale University School of Medicine wrote a blog post about ASMR, asking “the most basic question—is it real? In this case I don’t think there is a definitive answer, but I am inclined to believe that it is… It’s similar to migraine headaches—we know they exist as a syndrome primarily because many different people report the same constellation of symptoms and natural history.” He goes on to speculate as to what ASMR could be—possibly small seizures, or “just a way of activating the pleasure response.”
Many of those who experience ASMR report that some specific non-vocal ambient noises are also effective triggers of ASMR, including those like the sound of rain, fingers scratching or tapping a surface, the crushing of eggshells, the crinkling and crumpling of a flexible material such as paper, or writing. Many YouTube videos that are intended to trigger ASMR responses capture a single person performing these actions and the sounds that result.