Few legitimate studies have been done on ASMR, and even fewer have discussed the link between it and frisson specifically. At this time[when?], much of the data on ASMR comes from primarily anecdotal sources. Although ASMR and frisson are "interrelated in that they appear to arise through similar physiological mechanisms", individuals who have experienced both describe them as qualitatively different, with different kinds of triggers. A 2018 fMRI study showed that the major brain regions already known to be activated in frisson are also activated in ASMR, and suggests that "the similar pattern of activation of both ASMR and frisson could explain their subjective similarities, such as their short duration and tingling sensation".
But the phenomenon has nonetheless burst into the mainstream, thanks to mounting media coverage and a few high-profile references: “Saturday Night Live” alum Molly Shannon gushed to Conan O’Brien about her “head orgasms,” induced by the methodical touch of airport security pat-downs; novelist Andrea Seigel shared her experience with ASMR on the radio program “This American Life” last year; the “Dr. Oz” show has featured ASMR videos as a way to ease insomnia.
In 2012, Steven Novella, a neurologist at the Yale University School of Medicine wrote a blog post about ASMR, asking “the most basic question—is it real? In this case I don’t think there is a definitive answer, but I am inclined to believe that it is… It’s similar to migraine headaches—we know they exist as a syndrome primarily because many different people report the same constellation of symptoms and natural history.” He goes on to speculate as to what ASMR could be—possibly small seizures, or “just a way of activating the pleasure response.”