The first study to perform actual brain imaging (fMRI) on subjects currently experiencing ASMR tingles (as opposed to individuals who were merely able to experience the phenomenon) was published in BioImpacts in September 2018. Subjects viewed several ASMR videos with a screen and headphones while inside the MRI scanner. The study found a significant difference in brain activation between time periods when the subject reported tingling (communicated by pressing a button), as compared to time periods when they were watching a video but not reporting tingling (communicated by pressing a different button, to control for brain activation effects caused by merely pressing a button). They concluded that "the brain regions found most active during the tingling sensations were the nucleus accumbens, mPFC, insula and secondary somatosensory cortex", and suggested that these were similar to "activation of brain regions previously observed during experiences like social bonding and musical frisson".[29]
Given that ASMR is open to misunderstanding and misconceptions, a healthy dose of scepticism is important for future research in the area. Anecdotally, the Sheffield group point out that some ASMR enthusiasts use the videos therapeutically, to help with symptoms of insomnia, anxiety or depression. This is echoed in the findings from Barratt and Davis’s survey; their data showed that, for people who scored as having moderate to severe depression, 69% reported using ASMR videos to help ease their symptoms, and generally reported a greater improvement in mood than individuals who were not depressed. But these are self-report measures, and further work needs to be done to pinpoint to what extent there may be an actual therapeutic effect.
She uploads once a week to her channel and every week of the month is a different style video. She does true crime ASMR, tapping and scratching, videos where she reads and ones where she opens up about her life. "People enjoy more whenever it’s just me sitting there talking and like eating, and I get to just be myself and people enjoy it, that's pretty cool,” she said.

Allen verified in a 2016 interview that she purposely selected these terms because they were more objective, comfortable, and clinical than alternative terms for the sensation.[10] Allen explained she selected the word meridian to replace the word orgasm due to its meaning of point or period of greatest prosperity.[clarification needed][citation needed]

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